If just for hunting, and back up against predatory mammals, or the rare but drunken hunter the longer barreled high caliber weapons seem good options. The gentleman above recommended a .45LC Blackhawk. Other options may be a slightly more common .44 magnum or already addressed the 10mm. You might consider the S&W 500 magnum.
In 2011, while still a cop, I recall their being what we'll call an instigated ruckus with part of the town excited over a recent series of events. We were actually all standing around in the dispatch room discussing the matter, and one of our gallant officers voiced his chosen expletive, stated "I've got my back up" and pulled from his patrol bag a 500 magnum. Someone happened to say in return, again with his chosen expletive, "you could drop a bear with that thing."
As an aside, he had actually brought it to work to show off, but it could have served an added purpose.
Also, in line with the above, if you're looking for an EDC BUG then you'd be held to whatever else you could secret. If you choose IWB for a medium to larger frame handgun then you might opt for a subcompact in a pocket or the dreaded ankle holster.