I have had an iPhone since the 3gs and have had many types of cases. The Otterbox does an incredible job of protecting the phone but has three "flaws": 1) bulky (but that's part of what makes it work, I assume), 2) the plastic screen cover can inhibit the touch sensing but I didn't have too many problems with this, 3) it's not waterproof. My favorite case by far is the Lifeprood nuud for my iPhone 5 for three primary reasons: 1) much slimmer form factor, 2) NO plastic screen protector!! [this is good because it eliminates the problem of a screen protector hampering the touch screen; FWIW, the fre has previously had considerable issues with this and that is why the nuud was introduced in the first place], 3) waterproof!! the case comes with a test kit to ensure your case is waterproof. As a Fire Medic, I wanted the best protection I could get for my expensive phone. For me, the nuud is the best option by far.
As a sidenote, my pockets are full with "things" I prefer to carry daily so I require a holster. The Otterbox's only flaw with its side holster is the plastic piece that keeps the belt attachment open for sitting on a table so it can sit upright on its own is easily breakable. I had to replace my holster a couple of times because of this. The Lifeproof side holster has its issues as well though. I am on my third now. The first broke at the tabs that keep the holster from spinning freely. These tabs actually only offer resistance to rotation. The second broke where the belt loop connects at the holster.
What I can say for certain, is that Lifeproof backs their products. I contacted them via their website to get an RMA for these two holsters as they were under warranty. Just from my info I offered in the comments section, they sent me two replacement holsters and told me not to worry about sending the old ones in. This type of customer service alone is worth me purchasing their products!